The cost of a GP consultation was estimated to be £38 (including direct care staff costs and excluding qualification costs), taken from the PSSRU Unit Costs of Health and Social Care 2015. The assumption was made that all patients receiving chemoprevention would also incur the cost of two GP consultations per year while treatment was ongoing. The moderate-risk profile consisted of a 20 year old female patient who had not been tested for genetic mutations, and whose mother had also not been tested, but had been diagnosed with breast cancer at age 20. The high-risk BOADICEA profile consisted of a 20 year old female patient who had not been tested for genetic mutations, but whose mother had a confirmed BRCA1 mutation. Patient profiles in the BOADICEA tool were selected to produce lifetime breast cancer risks which were consistent with definitions of high- and moderate-risk patients in this guideline: high-risk patients are associated with a 30% or greater risk of breast cancer from age 20 and moderate-risk patients are associated with a risk of between 17% and 30%. These values were converted to one year risks in order to inform transition probabilities for the model. Baseline risk data are displayed in Table 18. Due to the scarcity of data on age-dependent baseline risk of breast cancer, five-year risks of breast cancer were generated using the BOADICEA assessment tool for representative high- and moderate-risk patients.
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